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Coexpression cluster:C2901: Difference between revisions

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|tf_chipseq_enrich=EBF1#1879;4:8.906466846569:0.0001588790747201:0.00200110608836138!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101663664671474!MAX#4149;4:6.45255550900712:0.000576761319564549:0.0048667993418439!NRF1#4899;4:12.2102794477109:4.49717228915276e-05:0.000795528754584731!RAD21#5885;4:10.3550338954563:8.6948481184721e-05:0.00129985863533511!USF1#7391;4:6.36149927720796:0.000610501139914083:0.00509184863052922!USF2#7392;4:12.9921973850696:3.50833029870167e-05:0.00068333925413298
|tf_chipseq_enrich=EBF1#1879;4:8.906466846569:0.0001588790747201:0.00200110608836138!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101663664671474!MAX#4149;4:6.45255550900712:0.000576761319564549:0.0048667993418439!NRF1#4899;4:12.2102794477109:4.49717228915276e-05:0.000795528754584731!RAD21#5885;4:10.3550338954563:8.6948481184721e-05:0.00129985863533511!USF1#7391;4:6.36149927720796:0.000610501139914083:0.00509184863052922!USF2#7392;4:12.9921973850696:3.50833029870167e-05:0.00068333925413298
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}}
}}

Revision as of 15:47, 26 November 2012


Full id: C2901_occipital_parietal_temporal_duodenum_non_brain_granulocyte



Phase1 CAGE Peaks

Hg19::chr7:69063408..69063445,+p1@AUTS2
Hg19::chr7:69063451..69063472,+p2@AUTS2
Hg19::chr7:69063473..69063494,+p5@AUTS2
Hg19::chr7:69063511..69063531,+p3@AUTS2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
nervous system3.17e-2989
central nervous system1.31e-2881
neural tube1.57e-2756
neural rod1.57e-2756
future spinal cord1.57e-2756
neural keel1.57e-2756
regional part of nervous system4.89e-2653
regional part of brain4.89e-2653
adult organism1.11e-25114
brain1.42e-2568
future brain1.42e-2568
neurectoderm5.54e-2486
neural plate1.56e-2382
presumptive neural plate1.56e-2382
regional part of forebrain9.02e-2241
forebrain9.02e-2241
anterior neural tube9.02e-2241
future forebrain9.02e-2241
telencephalon5.39e-2034
brain grey matter1.15e-1934
gray matter1.15e-1934
cerebral hemisphere6.16e-1932
regional part of telencephalon8.66e-1932
pre-chordal neural plate1.36e-1761
ectoderm-derived structure2.23e-17171
ectoderm2.23e-17171
presumptive ectoderm2.23e-17171
ecto-epithelium1.01e-16104
cerebral cortex2.35e-1525
pallium2.35e-1525
structure with developmental contribution from neural crest6.70e-15132
regional part of cerebral cortex5.72e-1422
neocortex4.58e-1320
organ system subdivision1.49e-10223
posterior neural tube5.26e-0715
chordal neural plate5.26e-0715
organ7.18e-07503


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187948.9064668465690.00015887907472010.00200110608836138
EGR1#195844.988179094810140.001615011500076050.0101663664671474
MAX#414946.452555509007120.0005767613195645490.0048667993418439
NRF1#4899412.21027944771094.49717228915276e-050.000795528754584731
RAD21#5885410.35503389545638.6948481184721e-050.00129985863533511
USF1#739146.361499277207960.0006105011399140830.00509184863052922
USF2#7392412.99219738506963.50833029870167e-050.00068333925413298



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.