Coexpression cluster:C428

Full id: C428_Endothelial_Renal_Lymphatic_Hepatic_adipose_heart_breast

Phase1 CAGE Peaks

Hg19::chr10:13908291..13908320,-	p@chr10:13908291..13908320 -
Hg19::chr12:6233727..6233738,-	p5@VWF
Hg19::chr12:6233757..6233771,-	p4@VWF
Hg19::chr12:6233828..6233843,-	p1@VWF
Hg19::chr12:6234045..6234103,-	p6@VWF
Hg19::chr12:71031185..71031215,-	p1@PTPRB
Hg19::chr12:71031220..71031229,-	p10@PTPRB
Hg19::chr12:71031247..71031262,-	p7@PTPRB
Hg19::chr12:80084018..80084035,-	p17@PAWR
Hg19::chr16:75285224..75285236,-	p@chr16:75285224..75285236 -
Hg19::chr1:208063620..208063634,-	p4@CD34
Hg19::chr21:39870339..39870443,-	p1@ERG
Hg19::chr21:39875765..39875785,+	p@chr21:39875765..39875785 +
Hg19::chr2:225266743..225266773,-	p1@FAM124B
Hg19::chr2:225266813..225266830,-	p2@FAM124B
Hg19::chr2:33661382..33661445,+	p3@RASGRP3
Hg19::chr4:56814149..56814167,-	p@chr4:56814149..56814167 -
Hg19::chr4:56814168..56814203,-	p@chr4:56814168..56814203 -
Hg19::chr5:61874637..61874685,+	p1@LRRC70 p2@IPO11
Hg19::chr5:66124590..66124644,+	p2@MAST4
Hg19::chr7:11871574..11871633,-	p3@THSD7A
Hg19::chr9:139538920..139538940,-	p@chr9:139538920..139538940 -
Hg19::chrX:10544942..10544977,-	p5@MID1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019899	enzyme binding	0.0128383398671892
GO:0005515	protein binding	0.0185725221551354
GO:0033093	Weibel-Palade body	0.0196043800777111
GO:0031091	platelet alpha granule	0.0294031075667311
GO:0046582	Rap GTPase activator activity	0.0352795745910804
GO:0002020	protease binding	0.0391949118586822
GO:0001948	glycoprotein binding	0.0499485389194682
GO:0043687	post-translational protein modification	0.0499485389194682

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
endothelial cell of vascular tree	3.69e-17	24
endothelial cell	5.42e-15	35
blood vessel endothelial cell	3.85e-13	18
embryonic blood vessel endothelial progenitor cell	3.85e-13	18
meso-epithelial cell	1.35e-09	44
lining cell	1.91e-07	57
barrier cell	1.91e-07	57
endothelial cell of artery	2.55e-07	9

Uber Anatomy

Ontology term	p-value	n
adult organism	3.29e-43	115
anatomical conduit	7.02e-20	241
tube	3.94e-18	194
circulatory system	3.18e-16	113
anatomical cluster	4.39e-16	286
neural tube	1.43e-15	57
neural rod	1.43e-15	57
future spinal cord	1.43e-15	57
neural keel	1.43e-15	57
cardiovascular system	6.07e-15	110
vessel	9.54e-15	69
endothelium	3.85e-13	18
blood vessel endothelium	3.85e-13	18
cardiovascular system endothelium	3.85e-13	18
splanchnic layer of lateral plate mesoderm	9.15e-13	84
regional part of brain	1.00e-12	59
anterior neural tube	2.13e-12	42
vasculature	2.64e-12	79
vascular system	2.64e-12	79
blood vessel	2.65e-12	60
epithelial tube open at both ends	2.65e-12	60
blood vasculature	2.65e-12	60
vascular cord	2.65e-12	60
neural plate	2.73e-12	86
presumptive neural plate	2.73e-12	86
regional part of forebrain	7.19e-12	41
forebrain	7.19e-12	41
future forebrain	7.19e-12	41
neurectoderm	9.77e-11	90
brain	3.31e-10	69
future brain	3.31e-10	69
central nervous system	5.44e-10	82
gray matter	7.68e-10	34
brain grey matter	7.68e-10	34
telencephalon	1.04e-09	34
lateral plate mesoderm	1.08e-09	216
simple squamous epithelium	1.21e-09	22
regional part of telencephalon	2.13e-09	33
cerebral hemisphere	5.50e-09	32
regional part of cerebral cortex	1.21e-08	22
pre-chordal neural plate	3.63e-08	61
neocortex	6.06e-08	20
epithelium	1.09e-07	309
anterior region of body	1.15e-07	129
craniocervical region	1.15e-07	129
epithelial tube	1.22e-07	118
regional part of nervous system	1.35e-07	94
nervous system	1.35e-07	94
cell layer	1.77e-07	312
squamous epithelium	1.88e-07	25
endothelial tube	2.55e-07	9
arterial system endothelium	2.55e-07	9
endothelium of artery	2.55e-07	9
head	7.13e-07	123

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.