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Coexpression cluster:C1480: Difference between revisions

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|tf_chipseq_enrich=ESR1#2099;3:15.3843016480772:0.000637403909579904:0.0052269022387418
|tf_chipseq_enrich=ESR1#2099;3:15.3843016480772:0.000637403909579904:0.0052269022387418
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|tfbs_overrepresentation_for_novel_motifs=0.44418,1.35536,0.436508,0.58616,1.01854,0.584466,0.662701,0.269608,0.267027,2.54809,0.553339,0.707204,0.223349,0.650887,0.391663,0.415981,0.889639,0.336106,0.236034,0.127969,0.436569,0.0880431,1.41165,0.387783,1.21515,0.730467,0.202389,0.574247,0.396295,0.547818,0.530785,0.92701,0.302275,0.640661,2.52957,2.82399,0.93226,1.43099,0.329602,1.28576,0.355745,0.513952,0.0979105,0.390088,1.41477,0.468392,0.66382,0.542147,0.0909286,0.396429,0.745008,0.675919,0.891214,1.00488,1.15929,0.653901,0.400834,0.62023,0.186533,0.619193,0.968558,0.666252,0.267534,2.00306,0.684675,0.826413,1.24834,1.61834,0.916468,1.45553,2.1621,0.275507,4.31331,1.15727,4.28285,1.12235,0.192925,0.84426,0.913168,0.477584,0.240887,0.86037,0.684313,0.272514,1.10535,2.07207,0.126687,0.536262,0.771626,1.71797,1.34233,1.07807,0.94406,0.30974,7.09564,0.32338,0.234532,0.987239,0.776336,0.166235,0.330999,0.938327,0.981588,0.893363,0.814675,0.548668,0.877269,0.647343,2.10687,0.376529,0.44815,0.978783,0.430775,0.563054,1.29401,0.352243,4.18682,0.529546,1.9262,0.312699,1.14892,0.769145,0.581628,0.695878,1.40534,0.845034,1.57878,0.949126,1.1919,0.324369,1.07876,0.53374,1.20639,0.692462,1.35529,0.175219,0.524606,0.57483,1.31259,2.17352,1.7705,1.27501,0.657956,0.983666,0.816466,0.611524,0.799467,2.01411,0.510514,2.2813,0.424432,7.63078,1.07915,0.258882,0.665754,1.48627,0.755083,0.378604,0.484017,1.15112,1.27379,1.06043,0.912368,0.457485,0.83286,0.683502,0.29379,0.661335,0.307168
}}
}}

Revision as of 14:55, 26 November 2012


Full id: C1480_optic_neuroectodermal_corpus_cerebellum_diencephalon_occipital_Astrocyte



Phase1 CAGE Peaks

Hg19::chr20:24449821..24449843,+p4@SYNDIG1
Hg19::chr20:24449953..24450011,+p2@SYNDIG1
Hg19::chr20:24450118..24450148,+p3@SYNDIG1
Hg19::chr20:24450259..24450346,+p1@SYNDIG1
Hg19::chr20:24450356..24450367,+p5@SYNDIG1
Hg19::chr20:24450498..24450540,+p@chr20:24450498..24450540
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
neural cell2.94e-0925
neurectodermal cell5.10e-0959
ectodermal cell8.35e-0772
Uber Anatomy
Ontology termp-valuen
nervous system1.47e-5589
central nervous system2.03e-5481
brain1.14e-4568
future brain1.14e-4568
neural tube1.29e-4556
neural rod1.29e-4556
future spinal cord1.29e-4556
neural keel1.29e-4556
neurectoderm1.52e-4386
regional part of nervous system7.38e-4353
regional part of brain7.38e-4353
neural plate2.96e-4182
presumptive neural plate2.96e-4182
ecto-epithelium1.62e-35104
adult organism2.51e-35114
ectoderm-derived structure3.22e-35171
ectoderm3.22e-35171
presumptive ectoderm3.22e-35171
regional part of forebrain4.79e-3241
forebrain4.79e-3241
anterior neural tube4.79e-3241
future forebrain4.79e-3241
structure with developmental contribution from neural crest3.49e-31132
telencephalon2.29e-3034
brain grey matter6.66e-3034
gray matter6.66e-3034
pre-chordal neural plate5.97e-2961
cerebral hemisphere2.29e-2832
regional part of telencephalon2.54e-2832
cerebral cortex8.22e-2325
pallium8.22e-2325
regional part of cerebral cortex5.58e-2122
neocortex1.94e-1920
organ system subdivision2.00e-17223
posterior neural tube2.08e-1415
chordal neural plate2.08e-1415
segmental subdivision of nervous system7.73e-1313
segmental subdivision of hindbrain7.64e-1212
hindbrain7.64e-1212
presumptive hindbrain7.64e-1212
anatomical cluster2.76e-10373
regional part of metencephalon2.21e-099
metencephalon2.21e-099
future metencephalon2.21e-099
tube7.94e-09192
basal ganglion1.54e-089
nuclear complex of neuraxis1.54e-089
aggregate regional part of brain1.54e-089
collection of basal ganglia1.54e-089
cerebral subcortex1.54e-089
neural nucleus1.71e-089
nucleus of brain1.71e-089
organ part1.74e-07218
multi-cellular organism1.97e-07656
cerebellum5.54e-076
rhombic lip5.54e-076
telencephalic nucleus5.76e-077
gyrus6.48e-076
temporal lobe6.97e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ESR1#2099315.38430164807720.0006374039095799040.0052269022387418



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.