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Coexpression cluster:C2509: Difference between revisions

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{{Coexpression_clusters
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|full_id=C2509_adipose_heart_lung_Renal_Endothelial_CD4_Hepatic
|id=C2509
}}

Latest revision as of 12:07, 17 September 2013


Full id: C2509_adipose_heart_lung_Renal_Endothelial_CD4_Hepatic



Phase1 CAGE Peaks

Hg19::chr1:101702417..101702481,+p1@S1PR1
Hg19::chr1:101702482..101702493,+p6@S1PR1
Hg19::chr1:101702501..101702512,+p5@S1PR1
Hg19::chr1:101702564..101702584,+p2@S1PR1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism4.77e-34114
circulatory system2.06e-18112
cardiovascular system3.99e-17109
neural tube2.17e-1456
neural rod2.17e-1456
future spinal cord2.17e-1456
neural keel2.17e-1456
vessel3.53e-1468
regional part of nervous system1.90e-1353
regional part of brain1.90e-1353
tube5.15e-13192
blood vessel endothelium8.96e-1318
endothelium8.96e-1318
cardiovascular system endothelium8.96e-1318
splanchnic layer of lateral plate mesoderm1.53e-1283
vasculature2.18e-1278
vascular system2.18e-1278
neural plate3.81e-1282
presumptive neural plate3.81e-1282
anatomical conduit6.65e-12240
epithelial tube open at both ends2.35e-1159
blood vessel2.35e-1159
blood vasculature2.35e-1159
vascular cord2.35e-1159
regional part of forebrain5.16e-1141
forebrain5.16e-1141
anterior neural tube5.16e-1141
future forebrain5.16e-1141
structure with developmental contribution from neural crest7.77e-11132
simple squamous epithelium2.67e-1022
central nervous system3.62e-1081
brain grey matter3.90e-1034
gray matter3.90e-1034
neurectoderm4.98e-1086
telencephalon1.34e-0934
nervous system2.54e-0989
brain2.75e-0968
future brain2.75e-0968
regional part of telencephalon3.76e-0932
cerebral hemisphere3.97e-0932
regional part of cerebral cortex3.97e-0822
pre-chordal neural plate5.38e-0861
squamous epithelium7.47e-0825
lateral plate mesoderm8.91e-08203
anatomical cluster2.10e-07373
endothelial tube2.35e-079
arterial system endothelium2.35e-079
endothelium of artery2.35e-079
neocortex3.19e-0720
ecto-epithelium3.59e-07104


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.11.92746
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.129.8833
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.13.18358
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.62583
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.92815
MA0145.11.70272
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.931615
MA0035.20.778873
MA0039.22.52211
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.21.65877
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.22.00408
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELF1#199744.258097958807540.003041525565781240.0160910738343866
FOS#235348.99795530889440.0001525147711168630.0019486775361725
PAX5#507946.669565531177830.0005052774169483260.00443935964908439
RAD21#5885410.35503389545638.6948481184721e-050.0012941160647643
TAF1#687243.343046285745290.008005664898701650.0322297292558593
TBP#690843.706770687096390.005296377814784350.0244280340310132
ZNF263#1012748.221841637010680.0002187871180958320.00248936788613254



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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