Coexpression cluster:C1784

Full id: C1784_heart_skeletal_left_tongue_diaphragm_cerebellum_temporal

Phase1 CAGE Peaks

Hg19::chr17:48172695..48172780,+	p1@PDK2
Hg19::chr19:35629684..35629701,+	p3@FXYD1
Hg19::chr19:35629702..35629742,+	p1@FXYD1
Hg19::chr19:35629748..35629760,+	p2@FXYD1
Hg19::chr19:35630028..35630083,+	p7@FXYD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	0.0192090723048097
GO:0018106	peptidyl-histidine phosphorylation	0.0192090723048097
GO:0018202	peptidyl-histidine modification	0.0192090723048097
GO:0004673	protein histidine kinase activity	0.0335181977945929
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	0.0335181977945929
GO:0043168	anion binding	0.0448719349502542
GO:0031404	chloride ion binding	0.0448719349502542

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
fat cell	5.61e-08	15

Uber Anatomy

Ontology term	p-value	n
adult organism	1.10e-65	114
neural tube	1.68e-32	56
neural rod	1.68e-32	56
future spinal cord	1.68e-32	56
neural keel	1.68e-32	56
regional part of nervous system	6.36e-30	53
regional part of brain	6.36e-30	53
neural plate	2.43e-26	82
presumptive neural plate	2.43e-26	82
brain	4.81e-25	68
future brain	4.81e-25	68
neurectoderm	5.57e-24	86
central nervous system	1.25e-23	81
regional part of forebrain	3.18e-23	41
forebrain	3.18e-23	41
anterior neural tube	3.18e-23	41
future forebrain	3.18e-23	41
organ system subdivision	7.12e-21	223
nervous system	1.13e-20	89
brain grey matter	2.30e-19	34
gray matter	2.30e-19	34
telencephalon	2.30e-19	34
structure with developmental contribution from neural crest	2.80e-19	132
ecto-epithelium	6.07e-19	104
cerebral hemisphere	7.21e-18	32
regional part of telencephalon	8.03e-18	32
multi-tissue structure	6.03e-16	342
regional part of cerebral cortex	2.55e-15	22
pre-chordal neural plate	5.25e-15	61
neocortex	9.15e-14	20
anatomical cluster	5.22e-13	373
ectoderm-derived structure	1.52e-12	171
ectoderm	1.52e-12	171
presumptive ectoderm	1.52e-12	171
cerebral cortex	1.58e-12	25
pallium	1.58e-12	25
organ	4.96e-12	503
anatomical conduit	2.67e-11	240
multi-cellular organism	4.09e-11	656
tube	1.09e-10	192
posterior neural tube	2.36e-10	15
chordal neural plate	2.36e-10	15
epithelium	1.47e-09	306
cell layer	2.03e-09	309
tissue	3.78e-09	773
anatomical system	5.99e-09	624
basal ganglion	7.00e-09	9
nuclear complex of neuraxis	7.00e-09	9
aggregate regional part of brain	7.00e-09	9
collection of basal ganglia	7.00e-09	9
cerebral subcortex	7.00e-09	9
anatomical group	7.70e-09	625
neural nucleus	1.08e-08	9
nucleus of brain	1.08e-08	9
segmental subdivision of nervous system	2.39e-08	13
segmental subdivision of hindbrain	6.78e-08	12
hindbrain	6.78e-08	12
presumptive hindbrain	6.78e-08	12
organ part	1.81e-07	218
telencephalic nucleus	4.06e-07	7

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
HNF4A#3172	3	13.8793742177722	0.000756140884743427	0.0059452381135074

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.