Coexpression cluster:C1784

Full id: C1784_heart_skeletal_left_tongue_diaphragm_cerebellum_temporal

Phase1 CAGE Peaks

Hg19::chr17:48172695..48172780,+	p1@PDK2
Hg19::chr19:35629684..35629701,+	p3@FXYD1
Hg19::chr19:35629702..35629742,+	p1@FXYD1
Hg19::chr19:35629748..35629760,+	p2@FXYD1
Hg19::chr19:35630028..35630083,+	p7@FXYD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	0.0192090723048097
GO:0018106	peptidyl-histidine phosphorylation	0.0192090723048097
GO:0018202	peptidyl-histidine modification	0.0192090723048097
GO:0004673	protein histidine kinase activity	0.0335181977945929
GO:0016775	phosphotransferase activity, nitrogenous group as acceptor	0.0335181977945929
GO:0043168	anion binding	0.0448719349502542
GO:0031404	chloride ion binding	0.0448719349502542

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	1.06e-48	115
neural tube	2.95e-25	57
neural rod	2.95e-25	57
future spinal cord	2.95e-25	57
neural keel	2.95e-25	57
regional part of brain	3.00e-23	59
neural plate	2.39e-22	86
presumptive neural plate	2.39e-22	86
brain	3.77e-22	69
future brain	3.77e-22	69
organism subdivision	4.45e-22	365
central nervous system	1.63e-21	82
neurectoderm	8.07e-21	90
regional part of nervous system	3.01e-20	94
nervous system	3.01e-20	94
anterior neural tube	1.61e-18	42
multi-tissue structure	4.17e-18	347
regional part of forebrain	4.33e-18	41
forebrain	4.33e-18	41
future forebrain	4.33e-18	41
anterior region of body	3.31e-17	129
craniocervical region	3.31e-17	129
head	1.76e-16	123
telencephalon	2.14e-15	34
pre-chordal neural plate	2.39e-15	61
gray matter	2.49e-15	34
brain grey matter	2.49e-15	34
anatomical cluster	7.22e-15	286
ectoderm-derived structure	7.56e-15	169
regional part of telencephalon	7.60e-15	33
cerebral hemisphere	2.24e-14	32
ectoderm	3.56e-14	173
presumptive ectoderm	3.56e-14	173
anatomical conduit	1.04e-12	241
regional part of cerebral cortex	2.17e-12	22
cell layer	3.68e-12	312
multi-cellular organism	4.47e-12	659
epithelium	6.46e-12	309
tube	1.53e-11	194
neocortex	2.44e-11	20
cerebral cortex	2.11e-10	25
pallium	2.11e-10	25
organ part	2.50e-10	219
organ	7.16e-10	511
anatomical system	1.09e-08	625
anatomical group	1.57e-08	626
posterior neural tube	6.32e-08	15
chordal neural plate	6.32e-08	15
embryo	1.82e-07	612
embryonic structure	9.36e-07	605
developing anatomical structure	9.36e-07	605
basal ganglion	9.72e-07	9
nuclear complex of neuraxis	9.72e-07	9
aggregate regional part of brain	9.72e-07	9
collection of basal ganglia	9.72e-07	9
cerebral subcortex	9.72e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
HNF4A#3172	3	13.8793742177722	0.000756140884743427	0.0059452381135074

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.