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Coexpression cluster:C4628: Difference between revisions

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|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00662642723324752!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00918902717552082!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0464772165237865!FOS#2353;3:8.9979553088944:0.00137249927241713:0.00901638265894908!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.0109154935768921!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128696456870321!IRF3#3661;3:46.9819522114896:9.63568551583244e-06:0.000254126605956572!NFYA#4800;3:18.4255806998305:0.000159813550781416:0.0020020112066763!NFYB#4801;3:16.7597932535365:0.000212364992329618:0.00246627237116791!RFX5#5993;3:12.0479108271951:0.000571724605031258:0.0048675589814021!SETDB1#9869;3:40.3200261780105:1.52461559299059e-05:0.000360003002297862!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0278188285638181!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0247819645474715!SP2#6668;3:26.1535304938446:5.58768218891694e-05:0.00094230896193815!SRF#6722;3:13.7971782621678:0.000380661502580019:0.00376333838204796!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0331098942593275!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140878763692516!ZEB1#6935;2:11.2589546783626:0.0101022267664633:0.0378254924627204
|tf_chipseq_enrich=CHD2#1106;3:10.3440228341169:0.000903370110274688:0.00662642723324752!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00918902717552082!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0464772165237865!FOS#2353;3:8.9979553088944:0.00137249927241713:0.00901638265894908!HMGN3#9324;3:8.17854772335059:0.00182776694216421:0.0109154935768921!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128696456870321!IRF3#3661;3:46.9819522114896:9.63568551583244e-06:0.000254126605956572!NFYA#4800;3:18.4255806998305:0.000159813550781416:0.0020020112066763!NFYB#4801;3:16.7597932535365:0.000212364992329618:0.00246627237116791!RFX5#5993;3:12.0479108271951:0.000571724605031258:0.0048675589814021!SETDB1#9869;3:40.3200261780105:1.52461559299059e-05:0.000360003002297862!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0278188285638181!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0247819645474715!SP2#6668;3:26.1535304938446:5.58768218891694e-05:0.00094230896193815!SRF#6722;3:13.7971782621678:0.000380661502580019:0.00376333838204796!YY1#7528;3:4.91117074985386:0.00844145534180826:0.0331098942593275!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140878763692516!ZEB1#6935;2:11.2589546783626:0.0101022267664633:0.0378254924627204
|tfbs_overrepresentation=0.147255,0.0586687,0.00948065,0.0477154,0.199763,0.287811,0.0430074,0.414564,0.03272,0.0257057,0.139423,0.225367,0.188771,0.125978,0.148679,0.0619003,0.140982,0.0982016,0.0528514,0.108057,0.188635,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.143747,0.0933697,0.204953,0.114046,0.0180314,0.208242,0.0665252,0.0844722,0.688181,0.0429682,0.120351,0.0667043,0.0964797,0.0246116,0.140039,0.184019,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.212709,0.0783235,0.105572,0.0294301,0.149417,0.108602,0.0759481,0.054569,0.0504887,0.352278,0.00183766,0.0860723,0.167053,0.378921,0.067678,0.00408688,0.119383,0.00747605,0.0171177,0.0964936,0.0436945,8.86152e-06,0.00725252,0.0956287,0.226912,0.0425,0.114846,0.291327,0.251834,0.064341,0.209032,0.608896,0.062747,0.0857568,0.0495878,0.0953825,0.0473737,0.0853887,0.115028,0.58489,0.153631,0.0927458,0.0415725,0.0574857,0.276221,0.141874,0.0370665,0.219088,0.0409286,0.0669887,0.338096,0.144217,0.269326,0.0177901,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.16671,0.214708,0.140123,0.0857827,0.00542817,0.176912,0.0906875,0.000109966,0.0843604,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.203923,0.155998,0.596561,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.0015841,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.227719,0.0952829,0.116642,0.147788,0.273479,0.114283,0.0400322,0.127369,0.0403542,0.312091,0.179689,0.137725,0.46397,0.0541353,0.0799324,0.090079,0.140334,0.00115947,0.178449,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.0737247,0.118847,0.183031,0.0401756,0.0828697,0.173562,0.107145,0.187297,0.122935,0.228812,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.259411,0.27358,0.15185,0.206299,0.0169462,0.0458667,0.104357,0.121154,0.1129,0.312578,0.0151713,0.164202,0.100942,0.062995,0.10299,0.14193,0.37245,0.15606,0.161026,0.0738599,0.126611,0.138852,0.085973,0.060453,0.059896,0.569726,0.0859236,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.263087,0.163502,0.214803,0.182472,0.00958651,0.0983991,0.0830921,0.116283,0.136838,0.0815104,0.111647,0.372804,0.117027,0.159052,0.185164,0.185743,0.0980288,0.0980899,0.159674,0.107242,0.201859,0.0695832,0.582402,0.0619218,0.1751,0.163376,0.128096,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,0.254773,0.0223286,0.0865903,0.0380459,0.130174,0.584917,0.713218,0.782949,0.268011,0.563047,0.823736,0.489965,0.335423,0.629514,0.261553,0.446302,0.373681,0.309233,0.49143,0.330703,0.395854,0.329568,0.53472,0.0724671,0.271958,0.292154,0.405773,0.39729,0.0582602,0.597171,0.187251,0.362792,0.181715,0.10624,0.109988,0.330894,0.218329,0.107929,0.376924,0.463191,0.0883629,0.528324,0.03861,0.370782,0.415647,0.142924,0.253571,0.276829,0.301787,0.481778,0.316882,0.223503,0.503224,0.0669244,0.283727,0.314747,0.577664,0.291709,0.448095,0.576651,0.416816,0.292835,0.476744,0.439556,0.373868,0.57762,0.608919,0.18237,0.706298,0.821217,0.747852,0.275351,0.236471,0.185661,0.346319,0.535598,0.270984,0.625945,0.503058,0.513852,0.522083,0.248634,0.281576,0.472384,0.163244,0.0670502,0.0730934,0.184794,0.230427,0.176034,0.581837,0.412837,0.671377,0.546839,0.551561,0.448039,0.218623,0.312808,0.117923,0.0451077,0.0747529,0.229003,0.650179,0.589326,0.0338328,0.294698,0.34331,0.477304,0.289204,0.327108,0.683186,0.278044,0.807485,0.428671,0.228096,0.336314,0.19763,0.15631,0.0106166,0.421464,0.48267,0.420626,0.516462,0.311758,0.335105,0.144809,0.145539,0.385517,0.376191,0.0224279,0.459928,0.252232,0.152681,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.546222,0.293698,0.284593,0.343734,0.306556,0.305777,0.06617,0.503082,0.522888,0.284629,0.262537,0.359455,0.226257,0.0965765,0.41707,0.363685,0.464871,0.753577,0.206222,0.525396,0.651524,0.437176,0.269226,0.339277,0.192529,0.281425,0.141758,0.455379,0.0385377,0.159617,0.238587,0.372281,0.232251,0.189515,0.0891382,0.0595618,0.524997,0.625309,0.347298,0.539392,0.34988,0.136757,0.404569,0.273024,0.0793778,0.316179,0.0697683,0.0556835,0.192544,0.0779981,0.0575676,0.144322,0.223391,0.203656,0.442884,0.441735,0.191777,0.111931,0.28934,0.0435386,0.303336,0.126478,0.134852,0.10689,0.273326,0.0627924,0.381386,0.0179103,0.303939,0.279795,0.390395,0.0464827,0.169603,0.114583,0.104559,0.0899537,0.0866966,0.15983,0.107111,0.0438639,0.00389058,0.123593,0.129156,0.0238665,0.193675,0.346372,0.0499762,0.0828956,0.0666953,0.182185,0.111277,0.219383,0.332809,0.19559,0.132201,0.188694,0.0481795,0.199971,0.406014,0.127758,0.175785,0.184486,0.169234,0.0876426,3.85844e-06,0.0112557,0.222432,0.107043,0.275244,0.00481323,0.173708,0.141119,0.211595,0.0300692,0.131551,0.0445237,0.052362,0.208866,0.153187,0.0797897,0.0974211,0.160149,0.123526,0.0906475,0.0558058,0.28262,0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}}
}}

Revision as of 16:51, 26 November 2012


Full id: C4628_gastric_lung_medulla_astrocytoma_cerebellum_spinal_pineal



Phase1 CAGE Peaks

Hg19::chr6:80247047..80247100,-p2@LCA5
Hg19::chr6:80247105..80247133,-p1@LCA5
Hg19::chr6:80247140..80247158,-p3@LCA5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
nervous system8.76e-3189
central nervous system4.47e-3081
adult organism8.99e-28114
neural tube3.59e-2656
neural rod3.59e-2656
future spinal cord3.59e-2656
neural keel3.59e-2656
ectoderm-derived structure1.08e-25171
ectoderm1.08e-25171
presumptive ectoderm1.08e-25171
brain8.80e-2568
future brain8.80e-2568
neurectoderm9.62e-2586
regional part of nervous system1.79e-2453
regional part of brain1.79e-2453
organ system subdivision2.66e-24223
neural plate5.46e-2482
presumptive neural plate5.46e-2482
anatomical cluster2.19e-23373
regional part of forebrain4.34e-2041
forebrain4.34e-2041
anterior neural tube4.34e-2041
future forebrain4.34e-2041
structure with developmental contribution from neural crest9.05e-20132
multi-tissue structure6.17e-18342
pre-chordal neural plate3.22e-1761
multi-cellular organism5.18e-17656
ecto-epithelium5.75e-17104
brain grey matter2.12e-1634
gray matter2.12e-1634
telencephalon3.09e-1634
regional part of telencephalon3.02e-1532
cerebral hemisphere3.66e-1532
anatomical conduit2.93e-13240
cerebral cortex3.45e-1225
pallium3.45e-1225
anatomical system4.81e-12624
regional part of cerebral cortex5.99e-1222
anatomical group6.20e-12625
embryo1.12e-11592
epithelium2.82e-11306
cell layer3.23e-11309
organ4.83e-11503
neocortex9.06e-1120
tube1.84e-10192
organ part2.82e-10218
developing anatomical structure6.70e-10581
embryonic structure8.44e-10564
germ layer1.37e-09560
germ layer / neural crest1.37e-09560
embryonic tissue1.37e-09560
presumptive structure1.37e-09560
germ layer / neural crest derived structure1.37e-09560
epiblast (generic)1.37e-09560
posterior neural tube2.79e-0715
chordal neural plate2.79e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00662642723324752
EBF1#187938.9064668465690.00141523283560980.00918902717552082
ELF1#199734.258097958807540.01295179875054610.0464772165237865
FOS#235338.99795530889440.001372499272417130.00901638265894908
HMGN3#932438.178547723350590.001827766942164210.0109154935768921
IRF1#365937.63716375356390.002244692747297240.0128696456870321
IRF3#3661346.98195221148969.63568551583244e-060.000254126605956572
NFYA#4800318.42558069983050.0001598135507814160.0020020112066763
NFYB#4801316.75979325353650.0002123649923296180.00246627237116791
RFX5#5993312.04791082719510.0005717246050312580.0048675589814021
SETDB1#9869340.32002617801051.52461559299059e-050.000360003002297862
SIN3A#2594235.408884726815140.006318961977991520.0278188285638181
SP1#666735.69838137814090.005403962701712170.0247819645474715
SP2#6668326.15353049384465.58768218891694e-050.00094230896193815
SRF#6722313.79717826216780.0003806615025800190.00376333838204796
YY1#752834.911170749853860.008441455341808260.0331098942593275
ZBTB7A#5134137.35190930787590.002516255860282270.0140878763692516
ZEB1#6935211.25895467836260.01010222676646330.0378254924627204



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.