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Coexpression cluster:C3889

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Full id: C3889_medial_hippocampus_cerebellum_brain_parietal_olfactory_caudate



Phase1 CAGE Peaks

Hg19::chr1:160093136..160093147,+p9@ATP1A2
Hg19::chr1:160104285..160104299,+p@chr1:160104285..160104299
+
Hg19::chr1:160111383..160111418,+p@chr1:160111383..160111418
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.70e-84115
neural tube1.03e-6657
neural rod1.03e-6657
future spinal cord1.03e-6657
neural keel1.03e-6657
central nervous system1.26e-6682
regional part of brain2.33e-6059
regional part of nervous system4.40e-5994
nervous system4.40e-5994
neural plate2.32e-5686
presumptive neural plate2.32e-5686
brain3.49e-5669
future brain3.49e-5669
neurectoderm4.91e-5390
regional part of forebrain1.16e-4741
forebrain1.16e-4741
future forebrain1.16e-4741
anterior neural tube2.92e-4642
gray matter1.82e-4334
brain grey matter1.82e-4334
telencephalon2.05e-4334
regional part of telencephalon7.69e-4233
cerebral hemisphere2.98e-4032
pre-chordal neural plate1.77e-3761
anterior region of body3.32e-37129
craniocervical region3.32e-37129
head7.22e-37123
regional part of cerebral cortex4.07e-3422
ectoderm-derived structure7.17e-34169
ectoderm1.30e-32173
presumptive ectoderm1.30e-32173
neocortex9.38e-3120
cerebral cortex2.59e-2925
pallium2.59e-2925
posterior neural tube7.01e-2115
chordal neural plate7.01e-2115
segmental subdivision of hindbrain3.64e-1612
hindbrain3.64e-1612
presumptive hindbrain3.64e-1612
tube6.04e-16194
basal ganglion8.20e-169
nuclear complex of neuraxis8.20e-169
aggregate regional part of brain8.20e-169
collection of basal ganglia8.20e-169
cerebral subcortex8.20e-169
nucleus of brain9.93e-169
neural nucleus9.93e-169
segmental subdivision of nervous system1.08e-1413
anatomical conduit1.50e-13241
telencephalic nucleus1.16e-127
organism subdivision1.58e-12365
anatomical cluster4.25e-12286
epithelium7.44e-12309
regional part of metencephalon1.24e-119
metencephalon1.24e-119
future metencephalon1.24e-119
cell layer1.48e-11312
gyrus1.56e-116
temporal lobe5.39e-117
brainstem1.12e-108
organ part1.21e-10219
limbic system9.33e-105
multi-tissue structure1.35e-09347
embryo1.38e-09612
multi-cellular organism1.47e-09659
parietal lobe2.96e-095
occipital lobe3.70e-095
corpus striatum2.91e-084
striatum2.91e-084
ventral part of telencephalon2.91e-084
future corpus striatum2.91e-084
organ5.61e-08511
anatomical system1.71e-07625
anatomical group1.94e-07626
cerebellum3.08e-076
rhombic lip3.08e-076
germ layer3.13e-07604
embryonic tissue3.13e-07604
presumptive structure3.13e-07604
epiblast (generic)3.13e-07604
embryonic structure3.55e-07605
developing anatomical structure3.55e-07605
middle temporal gyrus7.93e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.