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{{Coexpression_clusters
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|full_id=C3211_rhabdomyosarcoma_neuroblastoma_merkel_small_thalamus_smooth_diencephalon
|id=C3211
}}

Latest revision as of 12:21, 17 September 2013


Full id: C3211_rhabdomyosarcoma_neuroblastoma_merkel_small_thalamus_smooth_diencephalon



Phase1 CAGE Peaks

Hg19::chr11:94473567..94473660,+p@chr11:94473567..94473660
+
Hg19::chr11:94473668..94473693,+p@chr11:94473668..94473693
+
Hg19::chr11:94473701..94473744,+p@chr11:94473701..94473744
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
neural cell9.98e-0725
Uber Anatomy
Ontology termp-valuen
nervous system2.35e-3889
ectoderm-derived structure3.16e-36171
ectoderm3.16e-36171
presumptive ectoderm3.16e-36171
central nervous system1.61e-3481
neural tube1.41e-3256
neural rod1.41e-3256
future spinal cord1.41e-3256
neural keel1.41e-3256
neurectoderm6.32e-3286
regional part of nervous system1.08e-3053
regional part of brain1.08e-3053
neural plate8.08e-3082
presumptive neural plate8.08e-3082
brain2.00e-2968
future brain2.00e-2968
organ system subdivision4.47e-27223
adult organism1.00e-26114
regional part of forebrain6.94e-2541
forebrain6.94e-2541
anterior neural tube6.94e-2541
future forebrain6.94e-2541
ecto-epithelium2.35e-24104
structure with developmental contribution from neural crest1.12e-22132
pre-chordal neural plate6.25e-2261
telencephalon5.39e-2134
brain grey matter6.25e-2134
gray matter6.25e-2134
cerebral hemisphere7.56e-2032
regional part of telencephalon2.15e-1932
anatomical cluster4.15e-17373
organ part2.02e-15218
cerebral cortex1.70e-1425
pallium1.70e-1425
regional part of cerebral cortex6.82e-1322
organ5.36e-12503
neocortex9.25e-1220
multi-tissue structure1.12e-11342
multi-cellular organism2.20e-11656
embryo9.08e-11592
anatomical system8.21e-10624
anatomical group1.09e-09625
developing anatomical structure2.09e-09581
cell layer7.93e-09309
posterior neural tube8.77e-0915
chordal neural plate8.77e-0915
germ layer1.03e-08560
germ layer / neural crest1.03e-08560
embryonic tissue1.03e-08560
presumptive structure1.03e-08560
germ layer / neural crest derived structure1.03e-08560
epiblast (generic)1.03e-08560
embryonic structure1.03e-08564
epithelium4.14e-08306
neural nucleus4.96e-089
nucleus of brain4.96e-089
basal ganglion8.94e-089
nuclear complex of neuraxis8.94e-089
aggregate regional part of brain8.94e-089
collection of basal ganglia8.94e-089
cerebral subcortex8.94e-089
segmental subdivision of nervous system9.55e-0813
anatomical conduit1.18e-07240
segmental subdivision of hindbrain4.82e-0712
hindbrain4.82e-0712
presumptive hindbrain4.82e-0712
tube8.35e-07192


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.22681
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.80735
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.407479
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.70974
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.21.20011
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.13.52399
MA0163.12.48891
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.481578
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ZNF263#1012738.221841637010680.001799043925565870.0108978799688054



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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