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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.0724992894770213

Latest revision as of 11:45, 17 September 2013


Full id: C1443_Endothelial_lung_left_heart_adipose_spleen_mature



Phase1 CAGE Peaks

Hg19::chr18:53177984..53178004,-p17@TCF4
Hg19::chr6:46889579..46889591,-p6@GPR116
Hg19::chr6:46889608..46889626,-p4@GPR116
Hg19::chr6:46889646..46889657,-p5@GPR116
Hg19::chr6:46889663..46889686,-p2@GPR116
Hg19::chr6:46889694..46889719,-p3@GPR116


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism1.37e-71114
neural tube1.92e-3156
neural rod1.92e-3156
future spinal cord1.92e-3156
neural keel1.92e-3156
regional part of nervous system5.13e-2953
regional part of brain5.13e-2953
regional part of forebrain5.68e-2741
forebrain5.68e-2741
anterior neural tube5.68e-2741
future forebrain5.68e-2741
anatomical conduit1.92e-26240
tube1.92e-23192
neural plate3.72e-2382
presumptive neural plate3.72e-2382
brain grey matter5.26e-2334
gray matter5.26e-2334
anatomical cluster6.90e-23373
telencephalon8.69e-2334
regional part of telencephalon1.41e-2132
central nervous system1.96e-2181
cerebral hemisphere2.13e-2132
neurectoderm2.95e-2186
brain5.30e-2168
future brain5.30e-2168
nervous system2.36e-1989
structure with developmental contribution from neural crest6.84e-19132
regional part of cerebral cortex8.29e-1822
pre-chordal neural plate4.86e-1761
neocortex3.11e-1620
cerebral cortex3.85e-1625
pallium3.85e-1625
ecto-epithelium1.46e-15104
organ system subdivision1.05e-13223
epithelium2.49e-11306
cell layer5.90e-11309
multi-tissue structure3.32e-10342
multi-cellular organism5.13e-10656
lymphoid system5.26e-0910
blood vessel endothelium6.14e-0918
endothelium6.14e-0918
cardiovascular system endothelium6.14e-0918
ectoderm-derived structure8.74e-09171
ectoderm8.74e-09171
presumptive ectoderm8.74e-09171
anatomical system1.15e-08624
anatomical group1.39e-08625
neural nucleus2.05e-089
nucleus of brain2.05e-089
organ part2.15e-08218
basal ganglion3.98e-089
nuclear complex of neuraxis3.98e-089
aggregate regional part of brain3.98e-089
collection of basal ganglia3.98e-089
cerebral subcortex3.98e-089
lymphatic vessel1.08e-078
lymph vasculature1.08e-078
lymphatic part of lymphoid system1.08e-078
simple squamous epithelium1.26e-0722
compound organ2.35e-0768
telencephalic nucleus5.03e-077


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.0254709
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.12.3112
MA0051.13.90068
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.147053
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.11.24837
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.12.33031
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.00076337
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.32124
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.10.672893
MA0139.10.641617
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.107156
MA0146.10.093337
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.23.73007
MA0039.20.00570825
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.20.680553
MA0065.20.109623
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.819655
MA0155.10.0961854
MA0156.12.81343
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.347838
MA0163.10.0270301
MA0164.10.738243
MA0080.20.394469
MA0018.20.709805
MA0099.20.629739
MA0079.25.9246e-06
MA0102.21.58513
MA0258.10.289793
MA0259.10.336472
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR2A#543062.147453176558070.01019570676818780.0380296221129559



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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