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Coexpression cluster:C4378: Difference between revisions

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|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0323646367363606!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0321812730276214!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0464134267673718!NFKB1#4790;3:5.48806342419384:0.00604938181565543:0.0270423912787415!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109291724719018!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00616222538796394!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109787512295299
|tf_chipseq_enrich=E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0323646367363606!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0321812730276214!ELF1#1997;3:4.25809795880754:0.0129517987505461:0.0464134267673718!NFKB1#4790;3:5.48806342419384:0.00604938181565543:0.0270423912787415!SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0109291724719018!TCF7L2#6934;3:10.7701765631373:0.000800318129839838:0.00616222538796394!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109787512295299
|tfbs_overrepresentation=0.147255,0.0586687,3.12446e-15,0.0477154,8.60372e-05,0.287811,0.0430074,3.28139e-10,0.03272,0.000333258,0.139423,0.225367,0.188771,0.125978,0.148679,0.0619003,0.000522123,0.0982016,0.0528514,0.108057,0.188635,0.132577,0.081977,0.0948982,0.0415721,0.215492,0.209392,0.0907212,0.000554732,0.0933697,4.37092e-06,0.114046,0.0180314,0.208242,0.0665252,0.0844722,1.26312e-14,0.0429682,0.00755159,0.0667043,0.00481151,0.0246116,0.140039,0.0180778,0.120917,0.0362416,0.0380166,0.18151,0.111283,0.121201,0.154071,0.0541794,0.0701653,0.0929951,0.198787,0.0384161,0.107455,0.212709,0.0783235,0.00577992,0.0294301,0.149417,0.00612307,0.0759481,0.054569,0.0504887,0.0709764,0.0600088,0.0860723,0.000888001,0.000137668,0.067678,0.089036,0.119383,0.00747605,0.0171177,0.000161406,0.0436945,0.0372495,0.00725252,0.0956287,0.226912,0.0425,0.114846,0.0472875,0.251834,0.064341,0.0235519,5.63916e-05,0.062747,0.000112328,0.0495878,0.0953825,0.00114029,0.0853887,0.115028,0.0124566,0.153631,0.0927458,0.27413,0.0574857,0.0422457,0.141874,0.0370665,0.219088,0.00084924,0.0669887,0.00087036,0.144217,0.269326,0.182599,0.0339971,0.149552,0.0176855,0.101221,0.0337525,0.0203386,0.0566549,0.139021,0.0838393,0.00088228,0.214708,0.140123,0.0857827,0.00542817,0.176912,0.0906875,0.0147934,0.00366285,0.134932,0.0595773,0.0748346,0.0572164,0.0227861,0.125792,0.108101,0.0648644,0.0553359,0.0330399,0.00395526,0.022776,0.127606,0.00166778,0.155998,2.83261e-10,0.0693171,0.0988228,0.0842275,0.0389418,0.120833,0.0216297,0.143677,0.180712,0.0265818,0.0427088,0.117549,0.0747594,0.228385,0.0516985,0.0337251,0.0281563,0.0952829,0.116642,0.147788,0.273479,0.114283,0.0400322,0.127369,0.0403542,0.00660878,5.47631e-05,0.000485451,3.26339e-07,0.0541353,0.0799324,0.090079,0.140334,0.181817,2.07652e-06,0.0356339,0.158844,0.122474,0.0274061,0.115574,0.0737247,0.118847,0.183031,0.0401756,0.0828697,0.173562,0.107145,0.00127354,0.122935,1.17734e-11,0.112671,0.0470731,0.0782523,0.0602859,0.0676496,0.109673,0.0893019,0.060398,0.0308319,0.0606036,0.136451,0.259411,0.27358,0.15185,0.206299,0.0010913,0.0458667,0.104357,0.121154,0.1129,2.79553e-06,0.169057,0.0142864,0.100942,4.37286e-05,0.10299,0.0105855,0.00135672,2.86613e-08,0.0137227,0.0738599,0.126611,0.138852,0.085973,0.060453,0.059896,0.000243895,1.20585e-05,0.0418404,0.0765029,0.0959204,0.0931946,0.0472272,0.00377835,0.163502,0.0249262,0.182472,0.00958651,0.0983991,0.0830921,0.00703932,0.136838,0.0815104,0.111647,3.72169e-12,0.117027,0.159052,0.185164,0.00124042,0.0980288,0.0980899,0.159674,0.107242,0.201859,0.0695832,3.22083e-08,0.0619218,0.1751,0.163376,0.128096,0.0345133,0.0810678,0.0811639,0.0920653,0.118078,0.0755168,0.278352,0.063292,6.98499e-07,8.51121e-10,0.00386209,0.0380459,0.130174,0.0124596,6.68008e-12,8.28283e-08,3.46251e-13,1.0103e-10,5.90968e-10,0.0263372,6.76379e-05,1.06235e-06,0.00370732,0.00318602,0.0806291,0.00641099,0.0313047,0.330703,3.5194e-13,0.329568,0.53472,0.0164332,0.271958,0.292154,0.405773,0.0921263,0.0121013,0.00244849,0.187251,0.0109219,0.181715,2.44439e-05,0.109988,0.0620388,0.218329,0.107929,0.376924,0.025356,7.82194e-12,0.0407001,0.000977524,0.370782,0.00023908,0.000615629,0.00335333,0.276829,0.301787,0.00462582,0.00695027,0.223503,0.00574256,0.0146955,0.0447111,0.0557438,2.85707e-08,0.00529148,2.34717e-12,3.53364e-14,0.416816,0.00535876,5.90455e-05,0.439556,9.81031e-06,0.0116572,3.96699e-16,0.18237,6.2972e-11,5.65743e-11,0.000566966,0.00438172,0.236471,0.185661,8.53384e-10,1.27263e-07,0.00415948,0.0179843,0.000781971,1.07519e-05,0.000993751,0.248634,0.281576,0.472384,0.163244,0.0670502,0.0730934,0.184794,5.12179e-07,1.51896e-16,3.56085e-05,2.00964e-05,0.102184,0.188159,0.191921,0.120021,0.00208206,0.312808,0.000236487,0.0451077,0.0747529,0.229003,1.74e-07,0.223844,8.8271e-05,0.294698,0.0671437,0.138202,0.0465597,0.0077225,2.1078e-12,0.000362229,2.93451e-10,0.00262586,3.97812e-10,0.336314,0.0209597,0.0129079,2.4658e-14,0.000260039,0.0293525,0.000256922,1.12737e-05,3.03542e-17,4.52973e-06,0.144809,0.145539,0.08628,0.376191,0.119597,0.0247309,0.252232,0.0122989,0.0465712,0.137098,0.259235,0.134788,0.0985856,0.0460163,0.000461929,0.0450006,0.343734,0.306556,0.000553055,0.00257275,4.08988e-09,0.169823,0.284629,8.54043e-07,0.0741332,0.226257,0.016014,0.102469,0.00121543,0.000474832,3.28531e-08,0.206222,1.22049e-06,1.49053e-09,3.06818e-05,0.269226,0.0654598,2.11988e-06,1.36436e-06,0.141758,0.0238793,0.00680512,0.159617,0.238587,0.0799758,0.0293409,0.189515,0.0891382,0.0595618,0.171389,6.7723e-10,5.81843e-06,0.182325,0.00101759,5.22751e-06,0.0958562,0.0204872,1.06424e-07,0.0562865,0.0697683,0.0556835,0.192544,0.0779981,0.0575676,0.000561685,0.223391,4.2235e-06,4.02691e-11,3.31512e-05,0.191777,0.111931,1.64711e-06,0.0435386,0.303336,0.126478,0.0095312,6.21736e-06,0.273326,0.0627924,0.0842821,0.0179103,3.8523e-05,0.279795,0.0886747,0.0464827,0.00093131,0.114583,0.00566743,0.0899537,0.0866966,0.15983,0.0059529,0.0438639,0.00389058,0.123593,0.129156,0.0238665,0.0200986,0.346372,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|tfbs_overrepresentation_for_novel_motifs=0.699513,0.442617,0.690871,0.855819,0.641468,0.853988,0.937929,0.494933,0.491742,0.221898,0.820209,0.985163,1.94915,0.925331,0.639839,0.667627,1.17594,1.40888,0.452865,0.305559,0.69094,0.242883,0.845342,0.635379,0.743951,1.00973,1.05396,0.842925,0.645155,0.388328,0.795576,1.21459,1.3235,0.439574,0.599922,5.03488,0.596053,0.855276,0.567465,5.3038,0.598234,0.777097,0.259059,0.63803,0.151453,0.726632,2.16194,0.808003,0.247669,0.645308,1.02504,0.951993,0.336258,1.29475,1.45259,0.928548,0.650353,0.892517,0.388177,0.891404,1.25741,0.941709,0.492369,1.14672,0.961293,1.11026,1.54311,1.91674,1.2037,1.75271,0.762094,0.502203,0.333216,1.45054,0.430728,1.06461,1.02656,1.12884,1.20029,0.73687,0.459024,1.14559,0.960908,0.498519,1.39759,0.507157,0.303648,0.381882,1.053,2.0169,1.63834,1.36973,1.23218,0.543775,0.642354,1.37703,0.450952,1.27663,1.05794,4.5214,0.569121,1.22626,1.27082,1.1798,1.09802,0.815119,1.16312,0.921547,0.743661,0.622396,0.703975,1.26794,0.684398,0.830777,1.58942,0.594137,0.188952,0.794219,1.10778,0.547323,1.44203,1.0504,0.850918,0.973172,1.70203,1.12965,0.930979,1.2374,1.48578,0.561252,1.37044,0.798812,1.50051,0.969553,1.65144,0.372828,0.788803,0.843556,1.60823,2.47382,2.06967,1.57016,0.932872,1.27296,1.09989,0.883164,1.08214,2.31409,0.773313,0.539692,0.318511,0.698641,1.37083,0.481626,0.941179,1.78371,1.03563,0.624795,0.744018,0.710709,1.56892,1.35169,1.19946,0.714443,1.11698,0.960047,0.524529,0.936473,0.56135
}}
}}

Revision as of 16:42, 26 November 2012


Full id: C4378_migratory_Melanocyte_immature_Mast_Neutrophils_mesenchymal_corpus



Phase1 CAGE Peaks

Hg19::chr4:15004738..15004749,+p@chr4:15004738..15004749
+
Hg19::chr4:15004780..15004804,+p@chr4:15004780..15004804
+
Hg19::chr4:15004821..15004832,+p@chr4:15004821..15004832
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
myeloid leukocyte1.24e-1472
macrophage dendritic cell progenitor7.54e-1261
granulocyte monocyte progenitor cell1.08e-1167
monopoietic cell8.15e-1159
monocyte8.15e-1159
monoblast8.15e-1159
promonocyte8.15e-1159
myeloid lineage restricted progenitor cell1.44e-1066
defensive cell3.10e-0848
phagocyte3.10e-0848
Uber Anatomy
Ontology termp-valuen
adult organism6.69e-17114
neural tube2.43e-1656
neural rod2.43e-1656
future spinal cord2.43e-1656
neural keel2.43e-1656
regional part of nervous system4.53e-1553
regional part of brain4.53e-1553
neurectoderm7.34e-1486
skeletal system8.10e-14100
brain4.17e-1368
future brain4.17e-1368
bone marrow7.84e-1376
regional part of forebrain2.01e-1241
forebrain2.01e-1241
anterior neural tube2.01e-1241
future forebrain2.01e-1241
neural plate3.14e-1282
presumptive neural plate3.14e-1282
ectoderm-derived structure3.95e-12171
ectoderm3.95e-12171
presumptive ectoderm3.95e-12171
skeletal element6.76e-1290
nervous system6.84e-1289
central nervous system6.88e-1281
musculoskeletal system1.23e-11167
brain grey matter2.84e-1134
gray matter2.84e-1134
immune system3.00e-1193
hematopoietic system3.32e-1198
blood island3.32e-1198
telencephalon3.61e-1134
structure with developmental contribution from neural crest4.39e-11132
hemolymphoid system8.44e-11108
regional part of telencephalon3.25e-1032
bone element3.63e-1082
cerebral hemisphere5.18e-1032
ecto-epithelium6.79e-10104
pre-chordal neural plate7.54e-0961
embryonic structure8.90e-08564
germ layer9.68e-08560
germ layer / neural crest9.68e-08560
embryonic tissue9.68e-08560
presumptive structure9.68e-08560
germ layer / neural crest derived structure9.68e-08560
epiblast (generic)9.68e-08560
regional part of cerebral cortex4.18e-0722
cerebral cortex6.75e-0725
pallium6.75e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187635.017155731697390.00791769806886330.0323646367363606
EGR1#195834.988179094810140.008056488137383440.0321812730276214
ELF1#199734.258097958807540.01295179875054610.0464134267673718
NFKB1#479035.488063424193840.006049381815655430.0270423912787415
SPI1#668838.204323508522730.001810593189410520.0109291724719018
TCF7L2#6934310.77017656313730.0008003181298398380.00616222538796394
ZNF263#1012738.221841637010680.001799043925565870.0109787512295299



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.