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Coexpression cluster:C3959

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Full id: C3959_cerebral_occipital_middle_skeletal_parietal_hippocampus_medial



Phase1 CAGE Peaks

Hg19::chr1:247436728..247436776,+p@chr1:247436728..247436776
+
Hg19::chr1:6209302..6209306,-p@chr1:6209302..6209306
-
Hg19::chr5:149599188..149599192,-p@chr5:149599188..149599192
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
brain grey matter8.50e-9434
gray matter8.50e-9434
regional part of forebrain1.95e-8941
forebrain1.95e-8941
anterior neural tube1.95e-8941
future forebrain1.95e-8941
regional part of nervous system1.03e-8753
regional part of brain1.03e-8753
telencephalon2.82e-8734
cerebral hemisphere2.87e-8632
regional part of telencephalon4.24e-8632
neural tube1.06e-8256
neural rod1.06e-8256
future spinal cord1.06e-8256
neural keel1.06e-8256
brain8.48e-7568
future brain8.48e-7568
regional part of cerebral cortex1.35e-7422
neocortex7.22e-6620
central nervous system7.28e-6681
cerebral cortex2.01e-6525
pallium2.01e-6525
pre-chordal neural plate2.29e-6261
nervous system1.21e-5889
neural plate7.93e-5882
presumptive neural plate7.93e-5882
neurectoderm8.18e-5586
ecto-epithelium4.31e-44104
adult organism6.15e-43114
structure with developmental contribution from neural crest8.67e-38132
ectoderm-derived structure7.59e-31171
ectoderm7.59e-31171
presumptive ectoderm7.59e-31171
neural nucleus3.15e-299
nucleus of brain3.15e-299
gyrus2.48e-276
organ system subdivision3.00e-23223
basal ganglion6.13e-239
nuclear complex of neuraxis6.13e-239
aggregate regional part of brain6.13e-239
collection of basal ganglia6.13e-239
cerebral subcortex6.13e-239
parietal lobe2.18e-225
telencephalic nucleus1.05e-217
tube4.63e-19192
temporal lobe2.97e-166
limbic system4.55e-155
anatomical conduit7.07e-15240
occipital lobe8.65e-155
organ part1.35e-14218
frontal cortex1.46e-143
pons4.94e-133
multi-tissue structure2.66e-12342
epithelium8.97e-12306
cell layer1.39e-11309
anatomical cluster1.80e-11373
brainstem3.54e-116
corpus striatum1.62e-104
striatum1.62e-104
ventral part of telencephalon1.62e-104
future corpus striatum1.62e-104
Ammon's horn1.68e-102
lobe parts of cerebral cortex1.68e-102
hippocampal formation1.68e-102
limbic lobe1.68e-102
middle frontal gyrus1.93e-102
middle temporal gyrus2.12e-102
dorsal plus ventral thalamus6.88e-102
thalamic complex6.88e-102
globus pallidus1.40e-092
pallidum1.40e-092
locus ceruleus2.35e-092
brainstem nucleus2.35e-092
hindbrain nucleus2.35e-092
organ6.83e-07503
caudate-putamen7.38e-073
dorsal striatum7.38e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.