Coexpression cluster:C3984

Full id: C3984_carcinoid_merkel_neuroblastoma_parietal_medial_occipital_middle

Phase1 CAGE Peaks

Hg19::chr1:50513716..50513743,+	p5@ELAVL4
Hg19::chr1:50513788..50513817,+	p7@ELAVL4
Hg19::chr9:23821301..23821313,-	p6@ELAVL2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003730	mRNA 3'-UTR binding	1.31015399186089e-06
GO:0003729	mRNA binding	1.31249355256064e-05
GO:0003723	RNA binding	0.00743630928123174

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neuronal stem cell	7.98e-08	8
Merkel cell	3.36e-07	2
neuron	6.74e-07	6
neuroblast	6.74e-07	6
electrically signaling cell	6.74e-07	6

Uber Anatomy

Ontology term	p-value	n
nervous system	2.28e-64	89
central nervous system	4.29e-63	81
regional part of nervous system	4.47e-63	53
regional part of brain	4.47e-63	53
neural tube	1.50e-62	56
neural rod	1.50e-62	56
future spinal cord	1.50e-62	56
neural keel	1.50e-62	56
brain grey matter	2.67e-59	34
gray matter	2.67e-59	34
telencephalon	3.19e-59	34
regional part of forebrain	1.28e-58	41
forebrain	1.28e-58	41
anterior neural tube	1.28e-58	41
future forebrain	1.28e-58	41
cerebral hemisphere	4.41e-55	32
regional part of cerebral cortex	7.33e-55	22
brain	8.46e-55	68
future brain	8.46e-55	68
regional part of telencephalon	1.38e-54	32
neocortex	6.23e-50	20
cerebral cortex	9.25e-48	25
pallium	9.25e-48	25
neurectoderm	5.68e-46	86
neural plate	5.20e-44	82
presumptive neural plate	5.20e-44	82
pre-chordal neural plate	1.05e-41	61
ectoderm-derived structure	1.23e-36	171
ectoderm	1.23e-36	171
presumptive ectoderm	1.23e-36	171
ecto-epithelium	1.28e-36	104
adult organism	4.61e-36	114
organ system subdivision	6.78e-26	223
structure with developmental contribution from neural crest	9.10e-25	132
gyrus	1.62e-17	6
brainstem	2.50e-15	6
parietal lobe	2.62e-14	5
temporal lobe	2.71e-14	6
occipital lobe	2.92e-14	5
limbic system	5.15e-14	5
tube	1.21e-13	192
basal ganglion	3.28e-13	9
nuclear complex of neuraxis	3.28e-13	9
aggregate regional part of brain	3.28e-13	9
collection of basal ganglia	3.28e-13	9
cerebral subcortex	3.28e-13	9
neural nucleus	5.97e-13	9
nucleus of brain	5.97e-13	9
anatomical cluster	3.48e-11	373
organ part	5.64e-10	218
frontal cortex	1.19e-09	3
anatomical conduit	7.11e-09	240
pons	8.81e-09	3
telencephalic nucleus	1.09e-08	7
embryo	2.75e-08	592
medulla oblongata	3.09e-08	3
myelencephalon	3.09e-08	3
future myelencephalon	3.09e-08	3
posterior neural tube	1.32e-07	15
chordal neural plate	1.32e-07	15
segmental subdivision of hindbrain	2.67e-07	12
hindbrain	2.67e-07	12
presumptive hindbrain	2.67e-07	12
middle temporal gyrus	4.89e-07	2
middle frontal gyrus	5.17e-07	2
epithelium	5.50e-07	306
germ layer	6.73e-07	560
germ layer / neural crest	6.73e-07	560
embryonic tissue	6.73e-07	560
presumptive structure	6.73e-07	560
germ layer / neural crest derived structure	6.73e-07	560
epiblast (generic)	6.73e-07	560
cell layer	8.08e-07	309
embryonic structure	9.71e-07	564

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.